How DNA chemical tags shape early brain development
MECHANISMS OF EPIGENETIC REGULATION IN NERVOUS SYSTEM DEVELOPMENT
This work explores how specific DNA and histone chemical tags in brain cells influence development and may relate to autism in children.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11226579 on NIH RePORTER |
What this research studies
Researchers map special DNA methylation marks (especially methylation outside the usual CG sites) and related histone marks in neurons to see how they control which genes are turned on or off. They focus on autism-linked genes such as DNMT3A, MeCP2, NSD1, and ASH1L to learn how mutations change these epigenetic patterns. Laboratory experiments use neuronal cells and brain tissue models to track molecular changes and consequences for neuronal gene activity. Findings aim to connect molecular changes to altered brain development that could underlie features of autism.
Who could benefit from this research
Good fit: Although primarily laboratory-focused and not a treatment trial, the results are most relevant to children with autism spectrum disorder and related neurodevelopmental conditions.
Not a fit: People with medical issues unrelated to brain development or adults without neurodevelopmental concerns are unlikely to gain direct benefit from this lab-based project.
Why it matters
Potential benefit: If successful, this work could identify molecular mechanisms and potential targets that guide future therapies or diagnostics for autism spectrum and related neurodevelopmental disorders.
How similar studies have performed: Previous studies have linked neuronal DNA methylation and proteins like MeCP2 and DNMT3A to neurodevelopmental disorders, and this project builds on those established findings to explore new mechanisms.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Gabel, Harrison W — Washington University
- Study coordinator: Gabel, Harrison W
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.