How DNA and histone features affect transcription factor binding to nucleosomes
Influences of DNA sequence and histone features on transcription factor binding to nucleosomes
This study is looking at how certain DNA patterns and changes in proteins affect how special helpers called transcription factors can attach to DNA in cells, which could help us understand how genes are turned on or off during important processes like cell development, and this knowledge might lead to new treatments for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10883596 on NIH RePORTER |
What this research studies
This research investigates how specific DNA sequences and histone modifications influence the ability of transcription factors to bind to nucleosomes, which are structures that package DNA in cells. By developing advanced biochemical assays, the team aims to understand the mechanisms that allow certain transcription factors, known as pioneer factors, to access their target sites within nucleosomes. This knowledge could help clarify how gene expression is regulated during cell differentiation and other biological processes. Patients may benefit from insights gained about gene regulation that could lead to new therapeutic strategies.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with conditions related to gene expression dysregulation, such as certain cancers or genetic disorders.
Not a fit: Patients with conditions unrelated to gene expression or those not affected by transcription factor binding may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new approaches for treating diseases by enhancing our understanding of gene regulation.
How similar studies have performed: While the specific approach of this research is novel, there have been successful studies exploring the role of transcription factors and chromatin in gene regulation.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Bulyk, Martha L — Brigham and Women's Hospital
- Study coordinator: Bulyk, Martha L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.