How diuretics affect heart and kidney health in Veterans with CKD
Official title: Association of diuretics with change in extracellular volume, natriuretic peptides, symptoms, and cardiovascular outcomes in CKD
Funded at Michael E Debakey VA Medical Center · NIH-11235888 · Data updated 2026-11-12
This project looks at how diuretic medicines change body fluid, heart stress markers, symptoms, and heart/kidney outcomes in Veterans with chronic kidney disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michael E Debakey VA Medical Center NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | January 1, 2022 |
| Project end | December 31, 2026 |
| Funding year | 2027 |
| NIH project number | 5IK2CX002368-05 |
| Project ID | NIH-11235888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Veterans with chronic kidney disease who may require diuretic therapy and are capable of participating in clinical assessments.
✕Less likely to help
Patients not treated with diuretics or without CKD-related cardiovascular concerns may not benefit from this study.
What this research studies
A nephrologist at the VA is leading a plan to study how starting or increasing diuretics influences fluid status, heart-related biomarkers like BNP, symptoms, and cardiovascular outcomes in Veterans with CKD. The work will include hands-on training in clinical trial design, use of bioimpedance to measure extracellular volume, and advanced analysis techniques. The team emphasizes mentorship, coursework, and real-world experiences to prepare for VA Merit Review funding. This is a translational effort aiming to connect physiology changes with patient outcomes in a Veteran population.
Why it matters
Potential benefit: If successful, the research could clarify how diuretics affect heart and kidney health in CKD patients, guiding safer, more effective treatment.
How similar studies have gone: Previous similar approaches have shown that diuretics can influence fluid status and cardiac biomarkers, with variable effects on outcomes.
Where this research is happening
-
Michael E Debakey VA Medical Center
Houston, United States Active
Researchers
- Principal investigator: Gregg, Lucile Parker — Michael E Debakey VA Medical Center
- Study coordinator: Gregg, Lucile Parker
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.