How disruptions in the body's internal clock affect colorectal cancer
Circadian Clock Disruption and Colorectal Cancer
This study is looking at how changes in our body's natural daily rhythms might affect the growth of colorectal cancer, using special mice to help find new ways to treat the disease that could benefit patients like you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-10794252 on NIH RePORTER |
What this research studies
This research investigates the relationship between circadian clock disruptions and colorectal cancer development. By using a genetically engineered mouse model, the study aims to understand how changes in the body's natural rhythms can influence cell proliferation and the progression of colorectal tumors. The researchers will explore the molecular mechanisms involved in this process, which could lead to new targeted therapies for colorectal cancer. Patients may benefit from insights gained into how their daily rhythms could impact cancer risk and treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for colorectal cancer or those with early-stage colorectal tumors.
Not a fit: Patients with advanced colorectal cancer who are already undergoing aggressive chemotherapy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve treatment outcomes for colorectal cancer patients.
How similar studies have performed: Previous research has shown promising results in understanding the link between circadian rhythms and cancer, suggesting that this approach could yield significant insights.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Masri, Selma — University of California-Irvine
- Study coordinator: Masri, Selma
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.