How disruptions in our body clock may increase cancer risk from environmental factors
Circadian clock disruption: A risk factor for environmental carcinogenesis
['FUNDING_R01'] · NORTH CAROLINA STATE UNIVERSITY RALEIGH · NIH-10976405
This study is looking at how working different hours can mess with your body's natural clock and might increase the risk of skin cancer, helping us understand how this happens so we can find ways to protect people who work shifts.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NORTH CAROLINA STATE UNIVERSITY RALEIGH (nih funded) |
| Locations | 1 site (RALEIGH, UNITED STATES) |
| Trial ID | NIH-10976405 on ClinicalTrials.gov |
What this research studies
This research investigates how disruptions to the body's natural circadian clock, often caused by shift work, can lead to an increased risk of developing certain types of cancer, particularly skin cancer. The study focuses on understanding the biological mechanisms behind this connection, including how the circadian clock influences the body's ability to repair DNA damage caused by environmental factors like UV radiation. By examining genetic models, the researchers aim to uncover the pathways that are affected by circadian disruption and how they relate to cancer development. This research could provide insights into preventive strategies for those at risk due to their work schedules.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who work rotating shifts or have irregular sleep patterns and are concerned about their cancer risk.
Not a fit: Patients who do not have disrupted circadian rhythms or those not at risk for skin cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for reducing cancer risk in individuals with disrupted circadian rhythms.
How similar studies have performed: Previous studies have shown a connection between circadian disruption and cancer risk, indicating that this research builds on established findings in the field.
Where this research is happening
RALEIGH, UNITED STATES
- NORTH CAROLINA STATE UNIVERSITY RALEIGH — RALEIGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GADDAMEEDHI, SHOBHAN — NORTH CAROLINA STATE UNIVERSITY RALEIGH
- Study coordinator: GADDAMEEDHI, SHOBHAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancer Causing Agents, Cancer Induction, cancer initiation, cancer progression