How disruptions in daily rhythms affect insulin production in diabetes
Circadian disruption-induced mitochondrial dysfunction in diabetes
['FUNDING_R01'] · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · NIH-10873088
This study is looking at how changes in our daily body clock might affect insulin production and lead to diabetes, and it's aimed at helping people understand how keeping a regular routine could help prevent this condition.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PITTSBURGH AT PITTSBURGH (nih funded) |
| Locations | 1 site (PITTSBURGH, UNITED STATES) |
| Trial ID | NIH-10873088 on ClinicalTrials.gov |
What this research studies
This research investigates the link between circadian disruption and diabetes, focusing on how changes in daily biological rhythms can lead to dysfunction in insulin-producing beta cells. The study examines the role of the circadian clock in regulating the metabolic flexibility of these cells, which is crucial for their ability to respond to glucose. By using genetic models, the researchers aim to understand how disruptions in the circadian clock affect energy production and insulin secretion, potentially leading to diabetes. The findings could provide insights into new prevention strategies for diabetes related to lifestyle and circadian health.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for diabetes, particularly those experiencing circadian rhythm disruptions due to lifestyle factors.
Not a fit: Patients who do not have diabetes or are not at risk for metabolic syndrome may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or managing diabetes by addressing the impact of circadian rhythms on insulin production.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between circadian rhythms and metabolic health, suggesting that this approach could yield significant insights.
Where this research is happening
PITTSBURGH, UNITED STATES
- UNIVERSITY OF PITTSBURGH AT PITTSBURGH — PITTSBURGH, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YECHOOR, VIJAY K — UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- Study coordinator: YECHOOR, VIJAY K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.