How disrupted sleep affects gut health in ulcerative colitis
The Impact of Circadian Misalignment on Colonic Barrier Homeostasis in Ulcerative Colitis
['FUNDING_R01'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10951935
This study is looking at how changes in sleep patterns can affect gut health in people with ulcerative colitis, and it will involve participants experiencing simulated night shifts to see how their bodies respond compared to healthy individuals.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10951935 on ClinicalTrials.gov |
What this research studies
This research investigates how misalignment of the body's internal clock, particularly due to disrupted sleep patterns, impacts gut health in patients with ulcerative colitis. The study will involve human participants who will undergo controlled laboratory assessments to measure the effects of circadian misalignment on their gastrointestinal inflammation. By comparing the responses of ulcerative colitis patients to healthy individuals, the research aims to understand the relationship between sleep disruption and disease activity. Participants will experience simulated night shifts to observe changes in their gut health and circadian rhythms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mild to moderate ulcerative colitis who experience disrupted sleep.
Not a fit: Patients with severe ulcerative colitis or those not experiencing sleep disruptions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved management strategies for ulcerative colitis by addressing the impact of sleep patterns on disease flare-ups.
How similar studies have performed: Previous research has indicated a link between circadian rhythms and gastrointestinal health, suggesting that this approach may yield valuable insights.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SWANSON, GARTH R — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: SWANSON, GARTH R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Jetlag Syndrome, Time Zone Change Syndrome, Time Zone Syndrome, Jet Lag Syndrome