How disrupted body clocks affect immune cell movement in aging and Alzheimer's disease
Disrupted Circadian Regulation of Cell Migration at CNS-Immune Interfaces in Aging and Alzheimer's Disease
This study is looking at how our body's natural clock affects the movement of immune cells as we age and how this might relate to Alzheimer's disease, with the goal of finding early signs that could help in treating the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas at Austin NIH-funded |
| Lab location | 1 site (Austin, United States) |
| Project ID | NIH-11103374 on NIH RePORTER |
What this research studies
This research investigates the relationship between circadian rhythms and immune cell migration in the context of aging and Alzheimer's disease. It aims to understand how disruptions in the body's natural clock may contribute to inflammation in the central nervous system, which is linked to cognitive decline. By studying the patterns of immune cell movement, the research seeks to identify potential biomarkers for early intervention in Alzheimer's disease. The approach involves examining the biological processes that regulate these rhythms and their impact on health in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older, particularly those experiencing symptoms related to Alzheimer's disease or cognitive decline.
Not a fit: Patients under the age of 65 or those without any cognitive impairment or Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early intervention and treatment of Alzheimer's disease, potentially improving quality of life for patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in immune function, suggesting that this approach could yield valuable insights into Alzheimer's disease.
Where this research is happening
Austin, United States
- University of Texas at Austin — Austin, United States (Active)
Researchers
- Principal investigator: Fonken, Laura K — University of Texas at Austin
- Study coordinator: Fonken, Laura K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.