How disordered proteins interact with curved cell membranes
Dynamic Interactions between Intrinsically Disordered Proteins and Curved Membrane Surfaces
This study is looking at how certain proteins that don’t have a fixed shape interact with the curved surfaces of cell membranes, which is important for understanding how cells work and could help us learn more about diseases like cancer and neurological disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project ID | NIH-10893398 on NIH RePORTER |
What this research studies
This research investigates the role of intrinsically disordered proteins (IDPs) in cellular processes, particularly how they interact with curved membrane surfaces. By examining these interactions, the study aims to understand the dynamic behavior of IDPs in relation to cellular functions such as signaling and vesicle formation. The approach involves analyzing the biophysical properties of IDPs and their ability to sense membrane curvature, which is crucial for various physiological processes. This research could provide insights into the mechanisms underlying diseases linked to IDPs, including neurological disorders and cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals affected by neurological disorders or cancer that may be linked to the dysfunction of intrinsically disordered proteins.
Not a fit: Patients with conditions unrelated to intrinsically disordered proteins or membrane interactions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for diseases associated with intrinsically disordered proteins.
How similar studies have performed: While the study of intrinsically disordered proteins is gaining traction, the specific focus on their dynamic interactions with curved membranes is relatively novel and has not been extensively tested.
Where this research is happening
Los Angeles, UNITED STATES
- University of Southern California — Los Angeles, United States (Active)
Researchers
- Principal investigator: Zeno, Wade F — University of Southern California
- Study coordinator: Zeno, Wade F
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.