How disordered protein regions change RNA control in developmental disorders
Protein Disorder as a Modifier of RNA Binding and Regulation
This work looks at how flexible, disordered parts of RNA-binding proteins change gene control in ways that can lead to developmental disorders.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11331694 on NIH RePORTER |
What this research studies
Researchers at UNC Chapel Hill are studying RNA-binding proteins, focusing on their intrinsically disordered low-complexity regions and how those regions bind structured RNA elements. They combine lab biochemistry, molecular and computational biology, and relevant animal models to map how these interactions work across tissues. The team will also study disease-causing mutations and different protein isoforms to see how they alter RNA regulation. The goal is to define general rules of recognition that explain how mutations contribute to RBP-linked developmental disorders.
Who could benefit from this research
Good fit: People or families affected by developmental disorders linked to RNA-binding proteins who can donate clinical information or biological samples, or who want to be considered for future related studies, would be most relevant.
Not a fit: Patients without conditions related to RNA-binding proteins or those seeking immediate clinical treatments are unlikely to benefit directly from this basic laboratory research.
Why it matters
Potential benefit: If successful, this work could clarify causes of RNA-binding protein-related developmental disorders and point to new targets for diagnostics or future therapies.
How similar studies have performed: Previous basic-science studies have begun to show that disordered protein regions can mediate RNA interactions, but translating these findings into clinical interventions remains early-stage.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Dominguez, Daniel Issac — Univ of North Carolina Chapel Hill
- Study coordinator: Dominguez, Daniel Issac
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.