How different types of muscle cells affect recovery from leg blood flow issues after exercise therapy
Official title: Heterogeneity of Satellite Cell Populations Play a Role in Improvements in PAD after Exercise Therapy
Funded at Emory University · NIH-11011363 · Data updated 2026-11-12
This study is looking at how certain cells in your muscles can help improve blood flow and healing after exercise for people with peripheral artery disease (PAD), using animal models to learn more about how these cells work and how they can lead to better treatments for you.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | February 15, 2022 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $544,417 |
| NIH project number | 5R01HL155549-04 |
| Project ID | NIH-11011363 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with peripheral artery disease who are undergoing or considering exercise therapy.
✕Less likely to help
Patients with advanced PAD requiring immediate surgical intervention or those who cannot participate in exercise therapy may not benefit from this research.
What this research studies
This research investigates how various populations of satellite cells in skeletal muscle contribute to improvements in patients with peripheral artery disease (PAD) following exercise therapy. By using animal models, the study aims to understand the mechanisms behind these improvements, particularly focusing on how satellite cells promote blood vessel growth and healing. The research will also utilize advanced techniques like single-cell sequencing to analyze these cells in detail. Ultimately, the goal is to uncover the biological processes that enhance recovery and inform better treatment strategies for PAD patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective exercise-based therapies for patients with peripheral artery disease, improving their quality of life and reducing complications.
How similar studies have gone: Previous research has shown that exercise therapy can improve outcomes in PAD patients, but the specific role of satellite cells in this process is still being explored, making this approach novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Hansen, Laura Marie — Emory University
- Study coordinator: Hansen, Laura Marie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.