How different PP1 proteins and new human mutations affect nerve cell connections and memory
Protein phosphatase 1 isoforms, human de novo mutations and synaptic functions
This research looks at whether different forms of the PP1 protein and newly found human mutations change how brain cells connect and affect memory and thinking.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11289330 on NIH RePORTER |
What this research studies
Researchers will use genetically engineered mice, brain cell imaging, and biochemical tests to see how three PP1 enzyme forms (PP1α, β, γ) influence synapse development and signaling. They will test whether PP1β works with MYPT1 to limit spine maturation and synaptic transmission, and whether PP1γ and PP1α work with the scaffolding protein neurabin to promote spine growth, including effects at a specific neurabin site (Ser200). The team will also examine newly identified human de novo mutations to see if those changes alter PP1 function in ways that could explain cognitive deficits. Laboratory measures will be paired with animal behavior tests to link molecular changes to learning and memory outcomes.
Who could benefit from this research
Good fit: People who have been identified with de novo mutations in PP1-related genes or who have unexplained cognitive or memory problems would be the most relevant candidates for any human-focused parts of the project.
Not a fit: Patients with medical conditions unrelated to synaptic phosphorylation or without PP1-related genetic changes are unlikely to see direct benefits from this research in the near term.
Why it matters
Potential benefit: If successful, this work could reveal molecular targets behind some memory and cognitive problems and guide future diagnostic or treatment approaches.
How similar studies have performed: Prior animal studies altering PP1 and related phosphatases have shown effects on synapses and memory, but turning those findings into human treatments has not yet been achieved.
Where this research is happening
Rochester, United States
- University of Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Xia, Houhui — University of Rochester
- Study coordinator: Xia, Houhui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.