How different patterns of temporal lobe seizures spread in the brain
Official title: Impact of seizure onset pattern on temporal lobe seizure propagation through the basal ganglia
Funded at Emory University · NIH-10859473 · Data updated 2026-11-12
This study is looking at how seizures from the temporal lobe spread in the brain and how different patterns of these seizures affect that spread, with the hope of finding better treatment options for people with temporal lobe epilepsy who haven't had success with regular therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | September 11, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $674,409 |
| NIH project number | 1R01NS136529-01 |
| Project ID | NIH-10859473 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with temporal lobe epilepsy, especially those who have not responded to medication.
✕Less likely to help
Patients with other forms of epilepsy or those who have already achieved seizure control through existing treatments may not benefit from this research.
What this research studies
This research investigates the propagation of temporal lobe seizures through the basal ganglia, focusing on how different seizure onset patterns affect this process. By utilizing advanced imaging techniques and electrophysiological recordings, the study aims to uncover the mechanisms behind seizure spread and control. The goal is to enhance understanding of the brain networks involved in temporal lobe epilepsy, which could lead to more personalized treatment options for patients who do not respond to standard therapies. The findings may help identify which patients could benefit from surgical interventions or deep brain stimulation.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for patients with temporal lobe epilepsy, particularly those who are resistant to current therapies.
How similar studies have gone: Previous research has shown promise in understanding seizure propagation through brain networks, but this specific approach focusing on the basal ganglia is relatively novel.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Devergnas, Annaelle — Emory University
- Study coordinator: Devergnas, Annaelle
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.