How different nutrient levels affect the growth of human cytomegalovirus
Official title: Impact of diverse nutrient environment on viral replication and metabolite flow in human cytomegalovirus infection
Funded at University of Arizona · NIH-11001093 · Data updated 2026-11-12
This study is looking at how different levels of nutrients, like sugar, affect the way the human cytomegalovirus (HCMV) grows, especially in people with weakened immune systems and newborns, to help us find better ways to treat infections caused by this virus.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | September 30, 2023 |
| Project end | September 29, 2025 |
| Funding year | 2024 |
| Award (this year) | $74,284 |
| NIH project number | 5F32AI178919-02 |
| Project ID | NIH-11001093 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals who are immunocompromised or newborns at risk of congenital disabilities due to HCMV.
✕Less likely to help
Patients who are not infected with HCMV or do not have conditions related to viral infections may not benefit from this research.
What this research studies
This research investigates how varying nutrient environments influence the replication of human cytomegalovirus (HCMV), a virus that can cause serious health issues, especially in immunocompromised individuals and newborns. The study aims to understand how HCMV adapts its metabolism when nutrients like glucose are limited, which could reveal new insights into viral behavior and infection mechanisms. By using cell culture models, the research will explore how different nutrient conditions affect the virus's ability to replicate and produce viral components. This could lead to a better understanding of HCMV infections and potential therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to new treatment approaches for HCMV infections, particularly in vulnerable populations.
How similar studies have gone: While there has been research on viral metabolism, this specific approach of examining HCMV replication in low nutrient environments is relatively novel.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Mokry, Rebekah L — University of Arizona
- Study coordinator: Mokry, Rebekah L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.