How different formulations of cannabis edibles affect THC absorption and effects
The Impact of Product Formulation on the Pharmacokinetics and Pharmacodynamics of Delta-9THC-Infused Cannabis Edibles
This study is looking at how different types of cannabis edibles with delta-9-THC affect how your body absorbs and reacts to them, so if you use these products, you can better understand why they might feel different from one to another.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10706572 on NIH RePORTER |
What this research studies
This research investigates how the formulation of cannabis edibles, particularly those containing delta-9-THC, influences their absorption and effects in the body. By conducting a double-blind, placebo-controlled study, researchers will compare the pharmacokinetics (how the body absorbs and processes THC) and pharmacodynamics (the effects of THC on the body) of various edible formulations. The study aims to provide insights into why cannabis edibles can produce unpredictable effects and how formulation can impact user experience and safety.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who use or are interested in using cannabis edibles.
Not a fit: Patients who do not consume cannabis or are under the age of 21 may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective cannabis edibles, reducing the risk of adverse effects for consumers.
How similar studies have performed: While there is limited controlled clinical research on cannabis edibles, preclinical studies have shown promising results regarding the impact of formulation on THC absorption.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Spindle, Tory Richard — Johns Hopkins University
- Study coordinator: Spindle, Tory Richard
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.