How different forms of a protein affect neurodegenerative diseases
Effect of Agent and Host Factors on Alpha-Synuclein Strain Pathogenesis
This study is looking at how a protein called alpha-synuclein changes shape and spreads in the body, which can help us understand diseases like multiple system atrophy, with the hope of finding better treatments for people living with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Colorado State University NIH-funded |
| Lab location | 1 site (Fort Collins, United States) |
| Project ID | NIH-11088260 on NIH RePORTER |
What this research studies
This research investigates how the misfolding of the protein alpha-synuclein contributes to neurodegenerative diseases like multiple system atrophy. It aims to understand the mechanisms by which different strains of this protein spread in the body and affect the nervous system. By using advanced techniques to track the movement of these protein aggregates, the study seeks to uncover the factors that influence the severity and type of symptoms experienced by patients. This could lead to better understanding and potentially new treatments for those affected by these debilitating conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with multiple system atrophy or other synucleinopathies.
Not a fit: Patients with neurodegenerative disorders not related to alpha-synuclein misfolding may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic and therapeutic strategies for patients with neurodegenerative disorders.
How similar studies have performed: Previous research has shown promising results in understanding protein misfolding diseases, but this specific approach to studying alpha-synuclein strains is relatively novel.
Where this research is happening
Fort Collins, United States
- Colorado State University — Fort Collins, United States (Active)
Researchers
- Principal investigator: Woerman, Amanda L. — Colorado State University
- Study coordinator: Woerman, Amanda L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.