How Different Estrogen Levels Affect Body Processes
Dose-Dependent Effects of Hormone on the Activity of Estrogen Receptor Enhancers and Target Genes
This work explores how natural changes in estrogen levels affect various body tissues and their functions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ut Southwestern Medical Center NIH-funded |
| Lab location | 1 site (Dallas, United States) |
| Project ID | NIH-11130820 on NIH RePORTER |
What this research studies
This project aims to understand how different amounts of estrogen, similar to the natural fluctuations in a person's body, influence how cells work. Estrogen is important for many tissues, including reproductive organs, bones, and the brain, and plays a role in various diseases. While many studies use very high, unnatural levels of estrogen, this work focuses on physiological doses to see how they impact genes and cell activity. Researchers will look at how estrogen receptor proteins, which are key players in estrogen's actions, respond to these varying hormone levels to control gene expression. This will help us learn more about how estrogen truly affects our bodies.
Who could benefit from this research
Good fit: This foundational research does not directly involve patient participation, but its findings could eventually benefit individuals with conditions related to estrogen signaling, such as those affecting reproductive health, bone density, or certain cancers.
Not a fit: Patients seeking immediate treatment or direct clinical intervention would not find direct benefit from this basic science project.
Why it matters
Potential benefit: If successful, this work could lead to a better understanding of how estrogen influences health and disease, potentially guiding more effective hormone therapies.
How similar studies have performed: While the importance of hormone dose is recognized in therapy, the specific molecular and genomic effects of physiological estrogen doses are not well-characterized, making this a novel approach to a known area.
Where this research is happening
Dallas, United States
- Ut Southwestern Medical Center — Dallas, United States (Active)
Researchers
- Principal investigator: Kraus, William Lee — Ut Southwestern Medical Center
- Study coordinator: Kraus, William Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.