How dietary protein affects aging and metabolic health
Official title: Regulation of cellular senescence and metabolic health by dietary protein
Funded at University of Wisconsin-Madison · NIH-11059160 · Data updated 2026-11-12
This study is looking at how eating less protein, especially certain amino acids, might help older adults stay healthier and feel better as they age, by understanding how these changes can affect their cells and overall well-being.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | April 3, 2023 |
| Project end | April 2, 2026 |
| Funding year | 2025 |
| Award (this year) | $48,974 |
| NIH project number | 5F31AG082504-03 |
| Project ID | NIH-11059160 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who are interested in improving their metabolic health and overall well-being.
✕Less likely to help
Patients under the age of 65 or those with specific metabolic disorders unrelated to dietary protein may not benefit from this research.
What this research studies
This research investigates how dietary protein, particularly branched-chain amino acids, influences cellular aging and metabolic health in older adults. It aims to understand the mechanisms behind cellular senescence, a state that contributes to age-related diseases, and how dietary changes can potentially improve healthspan. By exploring the effects of protein restriction on cellular health, the study seeks to identify effective interventions that could enhance quality of life for seniors. Participants may be involved in dietary assessments and interventions to evaluate the impact on their health.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve health and longevity for older adults.
How similar studies have gone: Previous research has shown promising results in using dietary interventions to improve metabolic health and extend lifespan in animal models, suggesting potential for success in human applications.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Calubag, Mariah — University of Wisconsin-Madison
- Study coordinator: Calubag, Mariah
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.