How dietary protein affects aging and Alzheimer's disease
Official title: Investigating the Mechanistic Role of Dietary Protein in Aging and in Alzheimer's Disease
Funded at University of Wisconsin-Madison · NIH-10887191 · Data updated 2026-11-12
This study is looking at how the amount of protein we eat, especially a type called isoleucine, might help keep our brains healthy as we age and could help with Alzheimer's, using mice to learn more about how it works so we can find better eating habits for older adults.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2024 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $112,875 |
| NIH project number | 1K99AG084921-01A1 |
| Project ID | NIH-10887191 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 65 and above who may be experiencing cognitive decline or are at risk for Alzheimer's disease.
✕Less likely to help
Patients under 65 years of age or those without cognitive impairment may not benefit from this research.
What this research studies
This research investigates the impact of dietary protein on aging and Alzheimer's disease by examining how different levels of protein intake can influence metabolic health and cognitive function. The study focuses on a specific dietary component, isoleucine, to understand its role in promoting healthspan and potentially mitigating cognitive decline associated with aging and Alzheimer's. Using a mouse model, researchers will explore the molecular mechanisms behind these effects, aiming to identify dietary strategies that could enhance brain health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve cognitive health and longevity in older adults.
How similar studies have gone: Previous research has shown promising results regarding dietary interventions in aging and Alzheimer's, suggesting that this approach could yield significant insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Yeh, Chung-Yang — University of Wisconsin-Madison
- Study coordinator: Yeh, Chung-Yang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.