How dietary phosphorus and vitamin D affect calcium and phosphorus balance in people with chronic kidney disease.
Official title: Effects of Dietary Phosphorus Bioaccessibility and Calcitriol onPhosphorus and Calcium Whole-Body Balance and Kinetics in Moderate CKD
Funded at University of Minnesota · NIH-11061072 · Data updated 2026-11-12
This study is looking at how the foods we eat, especially phosphorus, and a hormone called calcitriol affect how your body handles calcium and phosphorus if you have moderate chronic kidney disease, with the goal of helping to keep your bones and heart healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | April 1, 2024 |
| Project end | January 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $656,007 |
| NIH project number | 5R01DK136800-02 |
| Project ID | NIH-11061072 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who are diagnosed with moderate chronic kidney disease.
✕Less likely to help
Patients with advanced chronic kidney disease or those not meeting the age criteria may not benefit from this research.
What this research studies
This research investigates how dietary phosphorus and the hormone calcitriol influence the balance and absorption of calcium and phosphorus in individuals with moderate chronic kidney disease (CKD). By conducting metabolic balance studies and using isotope tracers, the research aims to provide a clearer understanding of how these nutrients are processed in the body, particularly in relation to bone health and cardiovascular risks. The study will focus on the interactions between dietary intake and the body's regulatory mechanisms, which are crucial for managing CKD-related complications.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and treatments that enhance bone health and reduce cardiovascular risks for patients with chronic kidney disease.
How similar studies have gone: Previous research has shown that understanding the metabolic balance of calcium and phosphorus can lead to significant advancements in managing chronic kidney disease complications, indicating that this approach has potential for success.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Gallant, Kathleen M Hill — University of Minnesota
- Study coordinator: Gallant, Kathleen M Hill
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.