How dietary phosphorus and active vitamin D affect calcium and phosphorus balance in moderate chronic kidney disease
Effects of Dietary Phosphorus Bioaccessibility and Calcitriol onPhosphorus and Calcium Whole-Body Balance and Kinetics in Moderate CKD
['FUNDING_R01'] · UNIVERSITY OF MINNESOTA · NIH-11309995
This research looks at how cutting dietary phosphorus and giving active vitamin D change calcium and phosphorus handling in adults with moderate chronic kidney disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF MINNESOTA (nih funded) |
| Locations | 1 site (MINNEAPOLIS, UNITED STATES) |
| Trial ID | NIH-11309995 on ClinicalTrials.gov |
What this research studies
You would follow controlled diets with different types of phosphorus and, in some parts, receive calcitriol (active vitamin D) while researchers measure how much phosphorus and calcium your body absorbs, stores, or loses. The team will use metabolic balance testing and safe isotope tracers to separate intestinal absorption from bone formation and resorption. Tests include blood and urine collections, controlled meals, and specialized tracer studies that track nutrient movement among intestine, bone, kidney, and blood. The purpose is to explain why routine blood and urine tests miss key whole-body changes and to guide better diet and treatment decisions for bone and cardiovascular health in CKD.
Who could benefit from this research
Good fit: Adults (21+) with moderate chronic kidney disease who can follow controlled diets and attend clinic visits at the study center are the most likely candidates.
Not a fit: People with normal kidney function, those on dialysis or with very advanced kidney disease, or anyone unable to follow strict dietary protocols may not benefit or be eligible.
Why it matters
Potential benefit: Could lead to clearer dietary and vitamin D guidance to better protect bones and cardiovascular health in people with moderate CKD.
How similar studies have performed: Previous work often used blood and urine measures that miss whole-body fluxes, and while metabolic balance and isotope tracer methods have shown value elsewhere, applying them in CKD is less common and may provide new, more accurate insights.
Where this research is happening
MINNEAPOLIS, UNITED STATES
- UNIVERSITY OF MINNESOTA — MINNEAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: GALLANT, KATHLEEN M HILL — UNIVERSITY OF MINNESOTA
- Study coordinator: GALLANT, KATHLEEN M HILL
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Bone Diseases