How dietary fiber affects appetite and health through the microbiome

Mechanisms linking dietary fiber, the microbiome, and satiety

NIH-funded research University of Missouri-Columbia · NIH-11012344

This study is looking at how eating more fiber can help your gut health and control your appetite, which might lead to better heart and metabolic health, and it’s designed for anyone interested in how their diet can improve their overall well-being.

Quick facts

Grant typeCareer grant
Study typeNIH-funded research
Funding institutionUniversity of Missouri-Columbia NIH-funded
Lab location1 site (Columbia, United States)
Project IDNIH-11012344 on NIH RePORTER

What this research studies

This research investigates the relationship between dietary fiber intake, the gut microbiome, and appetite regulation. It aims to understand how high-fiber diets can improve cardiometabolic health by analyzing the production of short-chain fatty acids and changes in microbial composition. The study involves a team of experts who will utilize advanced techniques such as functional MRI and metabolomics to explore these connections. Patients may benefit from insights into how dietary changes can influence their health outcomes.

Who could benefit from this research

Good fit: Ideal candidates for this research are adults over 21 who are interested in improving their health through dietary changes, particularly those at risk for or managing conditions like adult-onset diabetes.

Not a fit: Patients who are not interested in dietary modifications or who have conditions that severely limit their ability to consume dietary fiber may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to dietary recommendations that significantly improve appetite control and reduce the risk of chronic diseases like diabetes and cardiovascular issues.

How similar studies have performed: Previous research has shown promising results linking high-fiber diets to improved health outcomes, indicating that this approach has potential for success.

Where this research is happening

Columbia, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions adult onset diabetesAdult-Onset Diabetes Mellitus
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.