How dietary fats influence the development of pancreatic cancer
Official title: Dietary fatty acids drive pancreatic cancer development
Funded at Yale University · NIH-10885200 · Data updated 2026-11-12
This study is looking at how different types of fats in our diets, especially oleic acid, might affect the growth of a serious type of pancreatic cancer, and it aims to help people understand how what they eat could influence their cancer risk.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 10, 2023 |
| Project end | June 30, 2028 |
| Funding year | 2024 |
| Award (this year) | $534,430 |
| NIH project number | 5R01CA276108-02 |
| Project ID | NIH-10885200 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a high risk of pancreatic cancer, particularly those with obesity or a history of high-fat diet consumption.
✕Less likely to help
Patients who are not at risk for pancreatic cancer or those with advanced stages of the disease may not benefit from this research.
What this research studies
This research investigates the relationship between dietary fatty acids and the development of pancreatic ductal adenocarcinoma (PDAC), a highly lethal form of cancer. By using a controlled panel of high-fat diets that vary only in fat source, the study aims to understand how specific dietary fats, particularly oleic acid, contribute to tumor growth in the pancreas. The research employs genetic models that closely mimic human PDAC progression, allowing for insights that could translate to human health. Patients may benefit from findings that clarify dietary influences on cancer risk and progression.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that help reduce the risk of pancreatic cancer.
How similar studies have gone: Previous research has shown that dietary factors can influence cancer development, but this specific approach focusing on the effects of different dietary fats on pancreatic cancer is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Muzumdar, Mandar Deepak — Yale University
- Study coordinator: Muzumdar, Mandar Deepak
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.