How diet patterns affect bone health
Bone as a target and mediator of the effects of diet manipulations
['FUNDING_P01'] · COLUMBIA UNIVERSITY HEALTH SCIENCES · NIH-11198011
This project looks at how calorie restriction and time‑restricted eating affect bone strength and bone hormones in adults.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | COLUMBIA UNIVERSITY HEALTH SCIENCES (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11198011 on ClinicalTrials.gov |
What this research studies
I want to know whether cutting calories or limiting eating times harms or helps my bones and the hormones bones release. The team uses animal experiments and lab studies of bone cells to trace molecular signals and links those findings to short human studies. They will compare effects by age and sex and study bone hormones such as osteocalcin and lipocalin‑2 that can affect blood sugar and energy use. The goal is to find which diet approaches preserve bone health while improving weight and glucose control.
Who could benefit from this research
Good fit: Adults trying calorie restriction or time‑restricted eating, especially older adults or people worried about bone loss or blood sugar, would be the most relevant candidates.
Not a fit: Children, pregnant people, or those without concerns about weight, metabolism, or bone loss are less likely to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could lead to safer diet recommendations that protect bone health while improving weight and blood sugar control.
How similar studies have performed: Previous work shows calorie restriction and time‑restricted eating can help weight and glucose control, but findings on bone health are mixed and mostly short‑term or done in animals.
Where this research is happening
NEW YORK, UNITED STATES
- COLUMBIA UNIVERSITY HEALTH SCIENCES — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DUCY, PATRICIA FLORENCE — COLUMBIA UNIVERSITY HEALTH SCIENCES
- Study coordinator: DUCY, PATRICIA FLORENCE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.