How diet and pressure affect gene expression in heart disease
The regulation of the histone code during cardiac hypertrophy
This study is looking at how what we eat and heart strain can change the way our genes work in both healthy and unhealthy hearts, with the hope of finding new ways to use diet to help manage heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rutgers Biomedical and Health Sciences NIH-funded |
| Lab location | 1 site (Newark, UNITED STATES) |
| Project ID | NIH-10983308 on NIH RePORTER |
What this research studies
This research investigates how dietary choices and pressure overload influence the histone code, which in turn affects gene expression in both healthy and failing hearts. By examining the modifications of histones, particularly in response to dietary fats, the study aims to understand how these changes can impact the progression of cardiac hypertrophy and failure. The researchers utilize advanced techniques like chromatin immunoprecipitation followed by sequencing (ChIP-seq) to analyze these modifications at a genomic level. This approach could lead to new insights into how diet can be used to manage heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with cardiac hypertrophy or heart failure, particularly those interested in how dietary changes might impact their condition.
Not a fit: Patients without any form of heart disease or those who are not interested in dietary interventions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide new dietary strategies to prevent or treat heart disease by targeting gene expression.
How similar studies have performed: Previous research has shown promising results in understanding the role of histone modifications in various diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Newark, UNITED STATES
- Rutgers Biomedical and Health Sciences — Newark, United States (Active)
Researchers
- Principal investigator: Abdellatif, Maha — Rutgers Biomedical and Health Sciences
- Study coordinator: Abdellatif, Maha
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.