How diet and metabolism affect HIV persistence and treatment
Impact of metabolic programing of T cells from the GI tract and related tissues on HIV reservoir seeding, maintenance and reactivation
This study is looking at how what you eat and your body's metabolism can affect your immune system and help us find better ways to manage HIV, so you can learn how your diet might improve your treatment results.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10685448 on NIH RePORTER |
What this research studies
This research investigates how metabolic programming of T cells in the gastrointestinal tract and related tissues influences the seeding, maintenance, and reactivation of HIV reservoirs. By examining the relationship between diet, immune responses, and HIV persistence, the study aims to uncover new strategies for eradicating the virus. Patients may benefit from insights into how their diet and metabolic health can impact their HIV treatment outcomes. The research employs a combination of clinical observations and laboratory assays to explore these connections.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are interested in understanding how their diet and metabolism may affect their condition.
Not a fit: Patients who are not living with HIV or those who are not engaged in treatment may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary and metabolic interventions that enhance HIV treatment and potentially contribute to a cure.
How similar studies have performed: Previous cases of HIV eradication, such as the Berlin and London patients, suggest that exploring metabolic and immune factors could lead to significant advancements in HIV treatment.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Apetrei, Cristian — University of Pittsburgh at Pittsburgh
- Study coordinator: Apetrei, Cristian
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.