How Diet and Environment Influence Gene Activity
Dynamics and molecular mechanisms linking metabolism and the epigenome
['FUNDING_OTHER'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-11126899
This project explores how the food we eat and signals from our environment can change how our genes are turned on or off.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-11126899 on ClinicalTrials.gov |
What this research studies
Our cells respond to nutrients and outside signals using a control system called the epigenome, which dictates specific gene expression. This project looks at how small molecules from our metabolism, influenced by diet and environment, interact with enzymes that modify our DNA and proteins. Understanding these interactions helps us see how changes in these metabolic molecules can alter gene activity. The goal is to uncover the exact ways these changes happen and how they might affect overall cell function.
Who could benefit from this research
Good fit: This foundational research does not directly involve patients, but future studies building on this work might seek individuals with conditions related to metabolism and gene regulation.
Not a fit: Patients seeking immediate treatment options would not directly benefit from this basic science project.
Why it matters
Potential benefit: If successful, this foundational understanding could lead to new ways to prevent or treat diseases influenced by diet and environmental factors.
How similar studies have performed: While the general concept of epigenetics is established, the specific mechanisms linking metabolic fluctuations to gene expression dynamics are still being uncovered.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENU, JOHN M — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: DENU, JOHN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.