How diet affects nerve activity related to gut and heart health.
Regulation of Viscerosensory Sympathetic Reflexes: The Role of Diet-Derived Lipid Mediators.
This study is looking at how certain fats in our diet affect blood pressure control in people with spinal cord injuries, especially those who might experience sudden high blood pressure due to their condition, and it hopes to find ways to help manage these blood pressure spikes better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wayne State University NIH-funded |
| Lab location | 1 site (Detroit, United States) |
| Project ID | NIH-10825514 on NIH RePORTER |
What this research studies
This research investigates the connection between diet-derived lipid metabolites and the nervous system's control over blood pressure, particularly in individuals with spinal cord injuries. It aims to understand how these dietary components influence the sympathetic nervous system's response to gut stimuli, which can lead to severe hypertension in patients experiencing autonomic dysreflexia. By studying the role of specific sensory neurons in this process, the research seeks to uncover mechanisms that could improve management of blood pressure crises in affected individuals.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with spinal cord injuries who experience autonomic dysreflexia.
Not a fit: Patients without spinal cord injuries or those not experiencing autonomic dysreflexia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better management strategies for blood pressure in patients with spinal cord injuries, potentially reducing the risk of hypertensive emergencies.
How similar studies have performed: Other research has shown promising results in understanding the role of diet and the nervous system in cardiovascular health, suggesting that this approach could yield valuable insights.
Where this research is happening
Detroit, United States
- Wayne State University — Detroit, United States (Active)
Researchers
- Principal investigator: O'leary, Donal S — Wayne State University
- Study coordinator: O'leary, Donal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.