How diet affects liver health and metabolism
Dietary regulation of the hepatic epigenome
['FUNDING_R01'] · UNIVERSITY OF WISCONSIN-MADISON · NIH-10640272
This study is looking at how certain amino acids in our diet can affect our metabolism and liver health, with the goal of finding new ways to help prevent obesity and diabetes, so people can learn about dietary changes that might improve their health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WISCONSIN-MADISON (nih funded) |
| Locations | 1 site (MADISON, UNITED STATES) |
| Trial ID | NIH-10640272 on ClinicalTrials.gov |
What this research studies
This research investigates how specific dietary amino acids influence metabolic health and the liver's genetic regulation. By examining the effects of restricting essential amino acids, such as methionine and branched-chain amino acids, the study aims to understand their role in preventing obesity and diabetes. The research will analyze changes in the liver's epigenome, metabolome, and transcriptome to uncover potential new treatments for metabolic disorders. Patients may benefit from insights into dietary interventions that could improve their health outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 who are at risk for or currently managing obesity or type 2 diabetes.
Not a fit: Patients who are not affected by obesity or diabetes may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to new dietary guidelines or treatments that help prevent or manage obesity and diabetes.
How similar studies have performed: Previous research has shown promising results in using dietary interventions to improve metabolic health, suggesting that this approach may be effective.
Where this research is happening
MADISON, UNITED STATES
- UNIVERSITY OF WISCONSIN-MADISON — MADISON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: DENU, JOHN M — UNIVERSITY OF WISCONSIN-MADISON
- Study coordinator: DENU, JOHN M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome