How diet affects gut bacteria and survival in colorectal cancer patients
Official title: Role of the inflammatory dietary pattern in gut and colon tissue microbiomes and impact on survival outcomes among colorectal cancer patients
Funded at Ohio State University · NIH-10947236 · Data updated 2026-11-12
This study is looking at how what you eat, especially if it causes inflammation, affects the bacteria in your gut and how that might influence the progression of colorectal cancer and your overall health, so if you're a colorectal cancer patient, your dietary habits could help us learn more about this connection.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 1, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $405,316 |
| NIH project number | 1R21CA294050-01 |
| Project ID | NIH-10947236 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with colorectal cancer who are willing to provide dietary information and participate in microbiome analysis.
✕Less likely to help
Patients with colorectal cancer who are not willing to engage in dietary assessments or microbiome testing may not benefit from this research.
What this research studies
This research investigates the relationship between dietary patterns, specifically inflammatory diets, and the gut microbiome in colorectal cancer (CRC) patients. By analyzing dietary habits and their impact on gut bacteria, the study aims to uncover how these factors influence cancer progression and patient survival. The research utilizes a novel scoring system to assess dietary inflammation and its correlation with tumor characteristics and patient outcomes. Patients may be asked to provide dietary information and undergo microbiome analysis to contribute to this important investigation.
Why it matters
Potential benefit: If successful, this research could lead to dietary recommendations that improve survival outcomes for colorectal cancer patients.
How similar studies have gone: Previous research has indicated that dietary patterns can significantly influence cancer outcomes, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Tabung, Fred Kinyuy — Ohio State University
- Study coordinator: Tabung, Fred Kinyuy
Related research
Other NIH-funded projects on the same topics.
-
Improving colorectal cancer screening and follow-up care.
This study is working to help more people get screened for colorectal cancer and receive the follow-up care they need, especially those who haven't been screened much before, so that everyone can have better access to important health checks and improve their overall health.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Ceramides and how they affect metabolism and colorectal cancer in adults
A study in adults with obesity-related health issues will explore how a fat-related molecule called ceramide influences metabolic problems and colorectal cancer risk.
-
Automated point-of-care DNA methylation test for colorectal cancer in LMICs
A fast, affordable blood test using DNA markers to help identify people at higher risk of colorectal cancer in low- and middle-income countries.
-
Rewiring Colorectal Cancer to Harness Therapeutic Hyperactivation
A Yale team is exploring brain-storming new ways to treat colorectal cancer by safely boosting certain cancer signaling pathways to kill cancer cells and by reshaping cancer cell states to improve responses to existing therapies.
-
Comparative modeling to guide colorectal cancer screening and care
A researcher team will use computer models to study how access to care, risk, and new screening options affect colorectal cancer outcomes and costs for adults in the US.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.