How diabetes speeds up kidney damage in people living with HIV
Elucidating the Molecular Mechanisms that Mediate DKD Progression in Patients Living with HIV
This project looks at blood and kidney samples from people living with HIV who also have diabetes, plus lab models, to find the molecular reasons diabetic kidney disease progresses faster in this group.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11235106 on NIH RePORTER |
What this research studies
If you have HIV and diabetes, researchers will compare gene activity in your blood and any available kidney samples with results from specialized lab mice to pinpoint what drives faster kidney damage. The team uses a mouse model that expresses low levels of HIV genes in kidney cells and will run bulk and single-cell RNA sequencing to see which cell types and pathways are affected. They will then compare those findings with samples from people living with HIV to confirm which molecular changes also occur in patients. The overall aim is to identify specific molecules that could be targeted by new treatments to slow or prevent diabetic kidney disease in people with HIV.
Who could benefit from this research
Good fit: Ideal participants are people living with HIV who have diabetes or early signs of kidney disease and who can provide blood samples or, in some cases, kidney biopsy tissue.
Not a fit: People without HIV, people without diabetes, and those with end-stage kidney disease already on dialysis are unlikely to benefit directly from this project.
Why it matters
Potential benefit: Could identify molecular targets that lead to new treatments to slow or prevent diabetic kidney disease in people living with HIV.
How similar studies have performed: Previous work showed HIV can persist in kidneys and that HIV plus diabetes worsens kidney disease in models and some patient data, but detailed molecular mapping in humans remains relatively new.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: He, John Cijiang — Icahn School of Medicine at Mount Sinai
- Study coordinator: He, John Cijiang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.