How diabetes and Alzheimer’s disease affect brain health in Latino adults
Official title: Effect of diabetes and AD pathology on brain imaging and cognition in Latino adults
Funded at University of Southern California · NIH-10503554 · Data updated 2026-11-12
This study is looking at how Type II diabetes might affect brain health and thinking skills in Latino adults, and it aims to find ways to help reduce the risk of memory problems in people with diabetes.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Southern California NIH-funded |
| Lab location | 1 site (Los Angeles, UNITED STATES) |
| Project start | September 30, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $3,755,733 |
| NIH project number | 1RF1AG078362-01 |
| Project ID | NIH-10503554 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are middle-aged Latino adults who have been diagnosed with Type II diabetes or are at risk for Alzheimer’s Disease.
✕Less likely to help
Patients who are not Latino or those who do not have Type II diabetes may not benefit from this research.
What this research studies
This research investigates the relationship between Type II diabetes mellitus (T2DM) and Alzheimer’s Disease (AD) in Latino adults, focusing on how these conditions impact brain health and cognitive function. The study will evaluate brain integrity, blood flow, and neurovascular function in 200 middle-aged Latino participants, comparing those with and without T2DM. Researchers will analyze changes in brain activity and blood markers after glucose ingestion to understand the mechanisms linking metabolic health to cognitive decline. The goal is to identify potential intervention targets to reduce the risk of cognitive impairment in this high-risk population.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing cognitive decline in Latino adults with diabetes.
How similar studies have gone: Previous research has shown promising results in understanding the links between diabetes and cognitive decline, but this specific focus on Latino adults is relatively novel.
Where this research is happening
-
University of Southern California
Los Angeles, United States Active
Researchers
- Principal investigator: Yassine, Hussein N — University of Southern California
- Study coordinator: Yassine, Hussein N
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.