How diabetes affects tendon properties through serum factors
Official title: Role of serum advanced glycation end-products in altering tendon properties with diabetes
Funded at Purdue University · NIH-10934566 · Data updated 2026-11-12
This study is looking at how certain substances in the blood of people with diabetes might affect the strength and flexibility of their tendons, with the goal of finding ways to help improve movement and overall quality of life for those living with diabetes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Purdue University NIH-funded |
| Lab location | 1 site (West Lafayette, United States) |
| Project start | September 25, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $588,861 |
| NIH project number | 5R01AR081967-02 |
| Project ID | NIH-10934566 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with diabetes who experience tendon-related complications.
✕Less likely to help
Patients without diabetes or those who do not have tendon issues may not benefit from this research.
What this research studies
This research investigates how advanced glycation end-products (AGEs) in the serum of individuals with diabetes impact the biomechanical properties of tendons. The study aims to understand the mechanisms by which AGEs activate specific receptors, leading to tendon complications. By examining human subjects and utilizing cell culture techniques, the research seeks to uncover the relationship between serum AGE levels and tendon function, ultimately aiming to improve mobility and quality of life for those affected by diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing tendon function and improving mobility in patients with diabetes.
How similar studies have gone: Previous research has indicated that serum factors like AGEs play a significant role in various complications associated with diabetes, suggesting a promising avenue for further exploration.
Where this research is happening
-
Purdue University
West Lafayette, United States Active
Researchers
- Principal investigator: Carroll, Chad Clayton — Purdue University
- Study coordinator: Carroll, Chad Clayton
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.