How diabetes affects people with glomerular (kidney) disease
The Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes
This project follows adults who have diabetes and one of four common glomerular diseases to learn how diabetes changes diagnosis, treatment, and outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11470948 on NIH RePORTER |
What this research studies
You would join a long-term observational group of adults who have diabetes plus one of these biopsy-proven kidney conditions: IgA nephropathy, focal segmental glomerulosclerosis, minimal change disease, or membranous nephropathy. The study collects clinical information, biopsy and tissue data, and biological markers over time and links that information to outcomes like infections, cardiovascular events, and kidney function. It is an add-on to the existing CureGN cohort and will also use comparison data from the TRIDENT diabetic kidney cohort to better understand differences related to diabetes. The goal is to fill a gap left by prior studies that excluded people with diabetes and to improve care for underrepresented groups and regions.
Who could benefit from this research
Good fit: Adults (age 21+) with diabetes and a biopsy-proven diagnosis of IgA nephropathy, FSGS, minimal change disease, or membranous nephropathy are the ideal candidates.
Not a fit: People without diabetes, children, patients with non-glomerular kidney diseases, or those already on long-term dialysis are unlikely to be eligible or to benefit directly from this project.
Why it matters
Potential benefit: If successful, the work could help doctors choose safer, more effective treatments and reduce complications for people who have both diabetes and glomerular disease.
How similar studies have performed: Large observational cohorts like the parent CureGN and the TRIDENT diabetic cohort exist, but including patients with preexisting diabetes in a dedicated glomerular disease cohort is a new and needed approach.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Mottl, Amy — Univ of North Carolina Chapel Hill
- Study coordinator: Mottl, Amy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.