How diabetes affects people with common glomerular (kidney) diseases
The Impact of Diabetes on Patients with Glomerular Disease: CureGN-Diabetes
This project follows adults with diabetes who also have one of four common glomerular kidney diseases to learn how diabetes changes diagnosis, treatment, and long-term outcomes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project ID | NIH-11398591 on NIH RePORTER |
What this research studies
If you are an adult (21+) with diabetes and a biopsy-confirmed glomerular disease like IgA nephropathy, FSGS, minimal change disease, or membranous nephropathy, the team will follow your health over time and collect medical records, biopsy details, and blood and urine samples. Researchers will link your data to existing CureGN and TRIDENT cohorts to compare how diabetes changes disease course, complications, and treatment responses. No experimental drugs are given — this is an observational study using clinical information and biological markers to find patterns that could guide future care. You may be asked to consent to share biopsy tissue and samples for research and to participate in periodic follow-up visits or data collection.
Who could benefit from this research
Good fit: Adults aged 21 and older with biopsy-proven IgA nephropathy, focal segmental glomerulosclerosis, minimal change disease, or membranous nephropathy who had diabetes at the time of kidney disease diagnosis.
Not a fit: People without diabetes, children, or patients with kidney diseases other than the four listed are unlikely to directly benefit from this project's specific findings.
Why it matters
Potential benefit: If successful, this work could help clinicians tailor treatments and reduce complications for people who have both diabetes and glomerular kidney disease.
How similar studies have performed: This builds on the CureGN and TRIDENT cohorts but combining diabetes with primary glomerular diseases has been under-studied, so the approach is relatively novel and fills a known gap.
Where this research is happening
Chapel Hill, United States
- Univ of North Carolina Chapel Hill — Chapel Hill, United States (Active)
Researchers
- Principal investigator: Mottl, Amy — Univ of North Carolina Chapel Hill
- Study coordinator: Mottl, Amy
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.