How diabetes affects infections caused by Group B Streptococcus in wounds
Official title: The Diabetic Wound Environment Shapes Group B Streptococcal Pathogenesis
Funded at University of Colorado Denver · NIH-11115717 · Data updated 2026-11-12
This study is looking at how the special conditions of diabetic wounds affect a common bacteria called Group B Streptococcus, which can cause infections, and it aims to help improve treatments for people with diabetes who have these wounds.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | June 13, 2024 |
| Project end | May 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $100,000 |
| NIH project number | 5K99AI180373-02 |
| Project ID | NIH-11115717 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who have developed chronic wounds or infections.
✕Less likely to help
Patients without diabetes or those who do not have chronic wounds may not benefit from this research.
What this research studies
This research investigates how the unique environment of diabetic wounds influences the behavior of Group B Streptococcus (GBS), a common bacterial pathogen in these infections. By studying mouse models, the research aims to understand how factors like immune response and high blood sugar levels contribute to GBS infections in diabetic patients. The project will explore the role of neutrophils, a type of immune cell, and how their altered function impacts the severity of infections. The findings could lead to better treatment strategies for diabetic wound infections.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic patients suffering from chronic wounds and reduce the risk of severe complications like amputations.
How similar studies have gone: Previous research has shown that understanding the specific interactions between bacteria and the diabetic wound environment can lead to significant advancements in treatment, indicating that this approach has potential for success.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Keogh, Rebecca — University of Colorado Denver
- Study coordinator: Keogh, Rebecca
Related research
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How diabetic wounds let Group B Streptococcus cause infections
Researchers are learning how high blood sugar, immune changes, and other bacteria in diabetic wounds help Group B Streptococcus grow and cause worse infections in people with diabetes.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.