How diabetes affects immune cells in tuberculosis
Macrophage metabolism in diabetes and tuberculosis comorbidity
['FUNDING_R21'] · UNIV OF ARKANSAS FOR MED SCIS · NIH-10911155
This study is looking at how diabetes might make it easier for tuberculosis to affect people by changing how certain immune cells in the lungs work, and it aims to find ways to help prevent tuberculosis in those with diabetes.
Quick facts
| Phase | ['FUNDING_R21'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF ARKANSAS FOR MED SCIS (nih funded) |
| Locations | 1 site (LITTLE ROCK, UNITED STATES) |
| Trial ID | NIH-10911155 on ClinicalTrials.gov |
What this research studies
This research investigates the relationship between diabetes and tuberculosis, focusing on how diabetes alters the metabolism of lung macrophages, which are crucial immune cells that respond to tuberculosis infection. The study aims to understand whether the increased susceptibility to tuberculosis in diabetic patients is linked to changes in the metabolic activities of these macrophages due to high blood sugar levels. By examining the immune response in diabetic conditions, the research seeks to identify potential strategies for preventing tuberculosis in diabetes patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are at risk of developing tuberculosis.
Not a fit: Patients without diabetes or those who do not have a risk of tuberculosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for tuberculosis in patients with diabetes.
How similar studies have performed: While the specific focus on macrophage metabolism in the context of diabetes and tuberculosis is novel, related research has shown that understanding immune cell function can lead to significant advancements in treating infectious diseases.
Where this research is happening
LITTLE ROCK, UNITED STATES
- UNIV OF ARKANSAS FOR MED SCIS — LITTLE ROCK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, LU — UNIV OF ARKANSAS FOR MED SCIS
- Study coordinator: HUANG, LU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Brittle Diabetes Mellitus