How diabetes affects breast tumor growth through changes in tissue structure
Diabetes Promotes Breast Tumor via Glycation-Induced Mechanical Changes in ECM
This study is looking at how high blood sugar levels in people with diabetes might affect breast cancer by changing the surrounding tissue, and it's hoping to find new ways to help improve treatment for those who have both conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project ID | NIH-10949098 on NIH RePORTER |
What this research studies
This research investigates the relationship between diabetes and breast cancer, focusing on how high blood sugar levels can alter the structure of the extracellular matrix (ECM) surrounding tumors. The study uses a mouse model to explore how glycation, a process where sugars bind to proteins, increases the stiffness of the ECM, which may promote tumor growth and spread. By understanding these mechanisms, the research aims to uncover potential therapeutic targets for improving outcomes in diabetic breast cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with both diabetes and breast cancer.
Not a fit: Patients without diabetes or those with non-breast cancer conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating breast cancer in patients with diabetes, potentially improving their prognosis.
How similar studies have performed: Previous studies have shown that understanding the mechanical properties of the ECM can lead to breakthroughs in cancer treatment, suggesting that this approach has potential for success.
Where this research is happening
Cambridge, United States
- Harvard University — Cambridge, United States (Active)
Researchers
- Principal investigator: Wang, Wenjun — Harvard University
- Study coordinator: Wang, Wenjun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.