How diabetes affects bone healing and regeneration
Diabetes, Macrophages and Bone Regeneration
['FUNDING_CAREER'] · UNIVERSITY OF ILLINOIS AT CHICAGO · NIH-10914683
This study is looking at how type 2 diabetes affects the healing of bones and soft tissues by examining special immune cells called macrophages, and it aims to find ways to help improve healing for people with diabetes by comparing how these cells work in healthy versus diabetic conditions.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF ILLINOIS AT CHICAGO (nih funded) |
| Locations | 1 site (Chicago, UNITED STATES) |
| Trial ID | NIH-10914683 on ClinicalTrials.gov |
What this research studies
This research investigates the impact of type 2 diabetes on the healing of bones and soft tissues, focusing on the role of macrophages, which are immune cells that influence healing outcomes. The study aims to understand how diabetic macrophages affect the differentiation of stem cells involved in bone regeneration. By analyzing the extracellular vesicles released by these macrophages, the research seeks to uncover mechanisms that could improve healing processes in diabetic patients. The approach includes comparing the effects of vesicles from healthy and diabetic macrophages on stem cell function.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with type 2 diabetes who are experiencing issues related to bone healing or regeneration.
Not a fit: Patients without diabetes or those not experiencing bone healing issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for bone healing in patients with diabetes.
How similar studies have performed: Previous research has shown promising results in understanding the immune system's role in bone healing, suggesting that this approach could yield valuable insights.
Where this research is happening
Chicago, UNITED STATES
- UNIVERSITY OF ILLINOIS AT CHICAGO — Chicago, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KANG, MIYA — UNIVERSITY OF ILLINOIS AT CHICAGO
- Study coordinator: KANG, MIYA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Adult-Onset Diabetes Mellitus