How diabetes affects blood vessel health and recovery after a stroke
Official title: Cerebrovascular O-GlcNAcylation Worsens Diabetes-associated Neurovascular Injury and Recovery Post-stroke
Funded at University of South Carolina at Columbia · NIH-11192972 · Data updated 2026-11-12
This study looks at how diabetes affects blood vessel health and recovery after a stroke, focusing on a specific change in proteins that might make things worse for diabetic patients; the goal is to find new ways to help these patients recover better after a stroke.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of South Carolina at Columbia NIH-funded |
| Lab location | 1 site (Columbia, United States) |
| Project start | September 26, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $511,702 |
| NIH project number | 1R56HL169223-01A1 |
| Project ID | NIH-11192972 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with diabetes who have experienced a stroke or are at high risk for stroke.
✕Less likely to help
Patients without diabetes or those who have not experienced a stroke may not receive direct benefits from this research.
What this research studies
This research investigates the impact of diabetes on the health of blood vessels and the recovery process following a stroke. It focuses on a specific modification called O-GlcNAcylation, which can alter the function of proteins involved in vascular health. By understanding how this modification worsens neurovascular injury in diabetic patients, the research aims to identify potential therapeutic targets to improve recovery outcomes. Patients with diabetes who experience strokes may benefit from insights gained through this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for diabetic patients who suffer from strokes, enhancing their recovery and reducing long-term complications.
How similar studies have gone: Previous research has shown that understanding vascular modifications in diabetes can lead to significant advancements in treatment strategies, indicating a promising avenue for this investigation.
Where this research is happening
-
University of South Carolina at Columbia
Columbia, United States Active
Researchers
- Principal investigator: Mccarthy, Cameron — University of South Carolina at Columbia
- Study coordinator: Mccarthy, Cameron
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.