How developing sperm cells control protein production
Novel mechanisms regulating translation elongation during male germ cell differentiation
['FUNDING_R01'] · RUTGERS, THE STATE UNIV OF N.J. · NIH-11319003
This project looks at how a protein called ADAD2 and small RNA-packed cell structures help developing sperm make the right proteins, which could matter for men with infertility.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | RUTGERS, THE STATE UNIV OF N.J. (nih funded) |
| Locations | 1 site (PISCATAWAY, UNITED STATES) |
| Trial ID | NIH-11319003 on ClinicalTrials.gov |
What this research studies
Scientists will study ADAD2, a protein that gathers in RNA-rich granules in developing sperm cells, to understand how it helps those cells make proteins correctly. They will use genetic models and laboratory techniques to isolate ribosomes and measure which messages are being read and translated into protein. The team will also map physical interactions between ADAD2 and other proteins that control the protein-making machinery. Findings aim to explain why loss of ADAD2 leads to germ cell loss and male infertility and may point to new diagnostic or treatment ideas.
Who could benefit from this research
Good fit: Men with unexplained problems in sperm development—for example those with post-meiotic germ cell loss, very low sperm counts, or unexplained non-obstructive azoospermia—would be most relevant to the findings and future related studies.
Not a fit: Patients whose infertility is due to anatomical blockages, known hormonal disorders, or female-factor infertility are less likely to benefit from this specific line of research.
Why it matters
Potential benefit: If successful, this work could reveal causes of some forms of male infertility and identify new targets for diagnosis or future therapies.
How similar studies have performed: Previous research has shown that controlling protein production is important for sperm development, but the specific role of ADAD2 and its unique granule is a new and not-yet-proven area.
Where this research is happening
PISCATAWAY, UNITED STATES
- RUTGERS, THE STATE UNIV OF N.J. — PISCATAWAY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SNYDER, ELIZABETH M, — RUTGERS, THE STATE UNIV OF N.J.
- Study coordinator: SNYDER, ELIZABETH M,
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.