How depression and early Alzheimer's affect driving in older adults

The Impact of Depression and Preclinical Alzheimer Disease on Driving Among Older Adults

NIH-funded research Washington University · NIH-10813732

This study is looking at how depression and early signs of Alzheimer's might affect driving skills in older adults, aged 65 and up, to help find ways to keep them safe on the road before any problems arise.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWashington University NIH-funded
Lab location1 site (Saint Louis, United States)
Project IDNIH-10813732 on NIH RePORTER

What this research studies

This research investigates the relationship between depression, preclinical Alzheimer's disease, and driving performance in older adults aged 65 and above. By using advanced imaging techniques and biomarkers, the study aims to identify individuals at risk of declining driving abilities before it happens. The goal is to develop interventions that can help prevent accidents and injuries among older drivers. The research highlights the importance of understanding how these factors interact to ensure safer driving for the aging population.

Who could benefit from this research

Good fit: Ideal candidates for this research are cognitively normal older adults aged 65 and above who may be experiencing depression or are at risk for Alzheimer's disease.

Not a fit: Patients who are not cognitively normal or who do not have any symptoms of depression or Alzheimer's disease may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved safety measures for older drivers, reducing the risk of accidents and enhancing their independence.

How similar studies have performed: Previous research has shown that understanding the impact of cognitive decline and mental health on driving can lead to significant improvements in safety for older adults, indicating that this approach has potential for success.

Where this research is happening

Saint Louis, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndrome
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.