How damaged mitochondria affect heart failure progression
Interplay between mitophagy and substrate utilization in heart failure progression
['FUNDING_R01'] · OHIO STATE UNIVERSITY · NIH-10980565
This study is looking at how the heart's ability to clean up damaged energy sources affects heart failure, and it's for anyone interested in understanding how changes in heart energy can lead to new treatments for heart disease.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OHIO STATE UNIVERSITY (nih funded) |
| Locations | 1 site (Columbus, UNITED STATES) |
| Trial ID | NIH-10980565 on ClinicalTrials.gov |
What this research studies
This research investigates the role of mitophagy, the process of clearing damaged mitochondria, in the progression of heart failure. It aims to understand how changes in the heart's energy sources, particularly the shift from fatty acids to glucose, impact mitophagy and overall heart function. By using a specialized mouse model, researchers will explore the connection between mitochondrial health and heart disease, potentially identifying new therapeutic targets for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults experiencing heart failure or related cardiac conditions.
Not a fit: Patients with heart conditions unrelated to mitochondrial dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and outcomes for patients with heart failure.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial function in heart disease, suggesting that this approach may yield valuable insights.
Where this research is happening
Columbus, UNITED STATES
- OHIO STATE UNIVERSITY — Columbus, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SUN, NUO — OHIO STATE UNIVERSITY
- Study coordinator: SUN, NUO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cardiac Diseases