How daily rhythms affect memory retrieval in the brain
Regulation of diurnal rhythms in parvalbumin and perineuronal net function
['FUNDING_R01'] · LEGACY EMANUEL HOSPITAL AND HEALTH CENTER · NIH-10980445
This study looks at how our body's internal clock affects our memory during the day, especially focusing on certain brain cells that help keep our daily rhythms in check, and it's aimed at understanding how problems with this clock might impact memory for people with irregular schedules or age-related changes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | LEGACY EMANUEL HOSPITAL AND HEALTH CENTER (nih funded) |
| Locations | 1 site (Portland, UNITED STATES) |
| Trial ID | NIH-10980445 on ClinicalTrials.gov |
What this research studies
This research investigates how the body's biological clock influences memory retrieval throughout the day. It focuses on specific brain cells called parvalbumin GABAergic neurons, which play a crucial role in regulating daily rhythms and cognitive functions. By studying these neurons and their surrounding structures, the research aims to understand how disruptions in circadian rhythms can lead to cognitive impairments, particularly in individuals with irregular schedules or age-related changes. The approach includes examining the patterns of these neurons and their interactions with circadian-associated genes in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults experiencing cognitive disturbances related to irregular sleep patterns, such as shift workers or those suffering from jet lag.
Not a fit: Patients with stable circadian rhythms and no cognitive impairments may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing memory and cognitive function in individuals affected by circadian rhythm disruptions.
How similar studies have performed: Previous research has shown promising results in understanding the role of circadian rhythms in cognitive functions, suggesting that this approach could yield valuable insights.
Where this research is happening
Portland, UNITED STATES
- LEGACY EMANUEL HOSPITAL AND HEALTH CENTER — Portland, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SORG, BARBARA A — LEGACY EMANUEL HOSPITAL AND HEALTH CENTER
- Study coordinator: SORG, BARBARA A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.