How daily rhythms affect memory retrieval in the brain
Official title: Regulation of diurnal rhythms in parvalbumin and perineuronal net function
Funded at Legacy Emanuel Hospital and Health Center · NIH-10980445 · Data updated 2026-11-12
This study looks at how our body's internal clock affects our memory during the day, especially focusing on certain brain cells that help keep our daily rhythms in check, and it's aimed at understanding how problems with this clock might impact memory for people with irregular schedules or age-related changes.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Legacy Emanuel Hospital and Health Center NIH-funded |
| Lab location | 1 site (Portland, UNITED STATES) |
| Project start | July 1, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $678,986 |
| NIH project number | 1R01NS131645-01A1 |
| Project ID | NIH-10980445 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include adults experiencing cognitive disturbances related to irregular sleep patterns, such as shift workers or those suffering from jet lag.
✕Less likely to help
Patients with stable circadian rhythms and no cognitive impairments may not benefit from this research.
What this research studies
This research investigates how the body's biological clock influences memory retrieval throughout the day. It focuses on specific brain cells called parvalbumin GABAergic neurons, which play a crucial role in regulating daily rhythms and cognitive functions. By studying these neurons and their surrounding structures, the research aims to understand how disruptions in circadian rhythms can lead to cognitive impairments, particularly in individuals with irregular schedules or age-related changes. The approach includes examining the patterns of these neurons and their interactions with circadian-associated genes in the brain.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for enhancing memory and cognitive function in individuals affected by circadian rhythm disruptions.
How similar studies have gone: Previous research has shown promising results in understanding the role of circadian rhythms in cognitive functions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Legacy Emanuel Hospital and Health Center
Portland, United States Active
Researchers
- Principal investigator: Sorg, Barbara a — Legacy Emanuel Hospital and Health Center
- Study coordinator: Sorg, Barbara a
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.