How daily rhythms affect brain activity and Alzheimer's disease
Circadian changes in network excitability and Alzheimer disease pathogenesis
This study is looking at how changes in our daily body clocks might affect brain activity and play a role in Alzheimer's disease, and it's for anyone interested in understanding more about how this condition develops.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11115853 on NIH RePORTER |
What this research studies
This research investigates how changes in daily biological rhythms influence brain activity and contribute to the development of Alzheimer's disease. By studying both human patients and animal models, the researchers aim to understand the mechanisms behind increased brain excitability that occurs in Alzheimer's. They will focus on the role of circadian rhythms and specific brain cells that may be disrupted in Alzheimer's patients, potentially leading to new insights into the disease's progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with Alzheimer's disease or those exhibiting early signs of cognitive decline.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that target circadian rhythms to improve brain health in Alzheimer's patients.
How similar studies have performed: Other research has shown promising results in understanding the role of circadian rhythms in neurological conditions, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Roberson, Erik D — University of Alabama at Birmingham
- Study coordinator: Roberson, Erik D
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.