How daily biological rhythms affect Alzheimer's disease and brain health
Official title: Neurovascular circadian oscillation in health and Alzheimer's disease
Funded at University of California, San Diego · NIH-10655154 · Data updated 2026-11-12
This study is looking at how our body's natural daily rhythms might affect the buildup of harmful substances in the brain that are linked to Alzheimer's disease, and it hopes to find clues that could help predict memory problems in older adults.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Diego NIH-funded |
| Lab location | 1 site (La Jolla, United States) |
| Project start | May 1, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,966,145 |
| NIH project number | 1RF1AG078241-01A1 |
| Project ID | NIH-10655154 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults, particularly those showing early signs of cognitive decline or diagnosed with Alzheimer's disease.
✕Less likely to help
Patients with other forms of dementia unrelated to Alzheimer's may not benefit from this research.
What this research studies
This research investigates the relationship between circadian rhythms and the blood-brain barrier in the context of Alzheimer's disease. It aims to understand how disruptions in daily biological cycles may influence the accumulation of harmful amyloid-beta plaques in the brain. By studying these interactions, the research seeks to uncover potential biomarkers that could predict cognitive decline in older adults. Patients may be monitored for changes in their sleep-wake patterns and other physiological responses as part of the study.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and intervention in Alzheimer's disease.
How similar studies have gone: Previous research has indicated a connection between circadian rhythm disruptions and Alzheimer's disease, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of California, San Diego
La Jolla, United States Active
Researchers
- Principal investigator: Daneman, Richard — University of California, San Diego
- Study coordinator: Daneman, Richard
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.