How cytoskeletal proteins evolve for specific roles in different tissues
Evolutionary Diversification of Cytoskeletal Proteins for Tissue-Specialized Roles
['FUNDING_OTHER'] · UT SOUTHWESTERN MEDICAL CENTER · NIH-11019434
This study looks at how certain proteins in our cells, especially those related to actin, change and adapt over time, focusing on their roles in fertility and development, using fruit flies and mammals to help us understand how these changes might affect our health.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UT SOUTHWESTERN MEDICAL CENTER (nih funded) |
| Locations | 1 site (DALLAS, UNITED STATES) |
| Trial ID | NIH-11019434 on ClinicalTrials.gov |
What this research studies
This research investigates the evolution and diversification of cytoskeletal proteins, particularly the actin-related protein superfamily, which play crucial roles in various cellular functions. By examining genetic variations in model organisms like Drosophila and mammals, the study aims to understand how these proteins adapt for specific tissue functions, especially in relation to fertility and development. The approach includes analyzing amino acid substitutions and their impact on protein function, which could reveal new insights into cellular processes that affect health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing difficulties conceiving or those with developmental issues potentially related to cytoskeletal protein functions.
Not a fit: Patients who do not have issues related to fertility or developmental disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for addressing fertility issues and developmental disorders linked to cytoskeletal protein functions.
How similar studies have performed: While the study of actin-related proteins is well-established, the specific focus on their rapid diversification and tissue specialization is a novel approach that has not been extensively explored.
Where this research is happening
DALLAS, UNITED STATES
- UT SOUTHWESTERN MEDICAL CENTER — DALLAS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHROEDER, COURTNEY MEGAN — UT SOUTHWESTERN MEDICAL CENTER
- Study coordinator: SCHROEDER, COURTNEY MEGAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.