How cytomegalovirus infection affects the colon's barrier function
Official title: Modulation of colonocyte barrier function and signaling by cytomegalovirus infection
Funded at University of Arizona · NIH-11060048 · Data updated 2026-11-12
This study is looking at how a virus called cytomegalovirus (CMV) affects the lining of the colon, which is important for keeping inflammation and disease at bay, especially in people with inflammatory bowel disease (IBD) or those getting cancer treatment, to find new ways to help manage related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Arizona NIH-funded |
| Lab location | 1 site (Tucson, United States) |
| Project start | April 1, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $543,101 |
| NIH project number | 5R01DK137411-02 |
| Project ID | NIH-11060048 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory bowel disease or cancer who are experiencing complications related to cytomegalovirus.
✕Less likely to help
Patients without a history of cytomegalovirus infection or those not suffering from inflammatory bowel disease or cancer may not benefit from this research.
What this research studies
This research investigates the effects of cytomegalovirus (CMV) infection on the barrier function of the colonic epithelium, which is crucial for preventing inflammation and disease. The study focuses on understanding how CMV alters the signaling and differentiation of cells in the colon, particularly in patients with inflammatory bowel disease (IBD) and those undergoing cancer treatment. By examining the mechanisms behind CMV's impact on the colon, the research aims to identify potential therapeutic targets for treating CMV-related colitis. This could lead to improved management strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from colitis related to cytomegalovirus infection.
How similar studies have gone: While the specific mechanisms of CMV's impact on colonic barrier function are not well-studied, related research has shown promise in understanding viral infections and their effects on gastrointestinal health.
Where this research is happening
-
University of Arizona
Tucson, United States Active
Researchers
- Principal investigator: Wilson, Jean M — University of Arizona
- Study coordinator: Wilson, Jean M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.