How cytomegalovirus (CMV) changes a cell's protein-making machinery.
Control of Translation in Herpesvirus Infected Cells - Resubmission - 1
['FUNDING_R01'] · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · NIH-11247961
The team is looking at how CMV hijacks the cell's protein-making process to help people at risk from CMV, like transplant patients, people with HIV, and babies born with infection.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | NEW YORK UNIVERSITY SCHOOL OF MEDICINE (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-11247961 on ClinicalTrials.gov |
What this research studies
This project studies human cytomegalovirus (HCMV) and how it alters the way infected cells make proteins. Researchers use viral and cell-based laboratory models to follow how ribosomes begin making viral and host proteins, focusing on the 5'-cap recruitment step. The team applies molecular biology, genetic, and biochemical methods to map the viral and host factors that drive these changes. Findings are intended to identify molecular targets that could be blocked to limit CMV replication.
Who could benefit from this research
Good fit: People most connected to this work include those with active CMV infection such as organ transplant recipients, people with HIV/AIDS, pregnant people at risk of passing CMV to their fetus, and newborns with congenital CMV.
Not a fit: People without CMV infection or those needing immediate clinical care are unlikely to receive direct benefit from this laboratory-focused research.
Why it matters
Potential benefit: If successful, this work could reveal new targets to stop CMV from replicating and lead to better treatments or preventive strategies for people at high risk.
How similar studies have performed: Using viral models like CMV to study translational control is well established and has produced important biological insights, though translating those findings into clinical therapies has been limited so far.
Where this research is happening
NEW YORK, UNITED STATES
- NEW YORK UNIVERSITY SCHOOL OF MEDICINE — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: MOHR, IAN J — NEW YORK UNIVERSITY SCHOOL OF MEDICINE
- Study coordinator: MOHR, IAN J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: CMV infection