How cytokines change mitochondrial function in cells
Cytokine-mediated reprogramming of mitochondrial function
This study is looking at how certain immune system signals can change the way our cells produce energy, especially in immune cells called macrophages, to help find new ways to treat chronic diseases related to inflammation and metabolism.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California Los Angeles NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10862590 on NIH RePORTER |
What this research studies
This research investigates how cytokines, which are signaling molecules in the immune system, can alter the function of mitochondria, the energy-producing structures in cells. The study focuses on understanding the mechanisms behind these changes, particularly in immune cells called macrophages, and how these changes can affect overall cell health and function. By exploring the relationship between cytokine signaling and mitochondrial activity, the research aims to uncover insights that could lead to new treatments for chronic diseases linked to inflammation and metabolic dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic inflammatory conditions or metabolic disorders.
Not a fit: Patients with acute infections or those not experiencing chronic inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for managing chronic diseases associated with inflammation and metabolic issues.
How similar studies have performed: Previous research has shown promising results in understanding the role of mitochondrial function in immune responses, indicating that this approach has potential for significant findings.
Where this research is happening
Los Angeles, United States
- University of California Los Angeles — Los Angeles, United States (Active)
Researchers
- Principal investigator: Divakaruni, Ajit — University of California Los Angeles
- Study coordinator: Divakaruni, Ajit
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.